PRIMARY BILIARY CIRRHOSIS
Article Sidebar
Main Article Content
Abstract
Primary Biliary Cirrhosis (PBC) is the result of long-standing damage to intra-hepatic biliary channels as a result
of immune mechanisms leading to cholestasis and its associated complications. It can end up in chronic liver disease
or cirrhosis. It usually manifests as pruritis that then proceeds to fatigue, jaundice and other features of chronic liver
disease. It is detected by raised serological markers of cholestasis and presence of anti-mitochondrial antibody (AMA)
in the blood. Some cases of AMA-negative PBC have also been reported though. Biopsy is diagnostic in such cases.
Overlap syndromes also occur, in which case two autoimmune conditions co-exist in the same liver. These include
autoimmune hepatitis (AIH) / PBC, AIH / Chronic Hepatitis C (CHC), AIH / Cryptogenic Chronic Hepatitis, and AIH /
Primary Sclerosing Cholangitis (PSC) overlaps. Treatment of PBC is primarily with ursodeoxycholic acid, though steroids
and steroid sparing
Article Details
All articles published in the Journal of Medical Sciences (JMS) are licensed under the Creative Commons Attribution 4.0 International License (CC-BY 4.0). Under the CC BY 4.0 license, author(s) retain the ownership of the copyright publishing rights without restrictions for their content, and allow others to copy, use, print, share, modify, and distribute the content of the article even for commercial purposes as long as the original authors and the journal are properly cited. No permission is required from the author/s or the publishers for this purpose. Appropriate attribution can be provided by simply citing the original article. The corresponding author has the right to grant on behalf of all authors, a worldwide license to JMS and its licensees in all forms, formats, and media (whether known now or created in the future), The corresponding author must certify and warrant the authorship and proprietorship and should declare that he/she has not granted or assigned any of the article’s rights to any other person or body.
The corresponding author must compensate the journal for any costs, expenses, or damages that the JMS may incur as a result of any breach of these warranties including any intentional or unintentional errors, omissions, copyright issues, or plagiarism. The editorial office must be notified upon submission if an article contains materials like text, pictures, tables, or graphs from other copyrighted sources. The JMS reserves the right to remove any images, figures, tables, or other content, from any article, whether before or after publication, if concerns are raised about copyright, license, or permissions and the authors are unable to provide documentation confirming that appropriate permissions were obtained for publication of the content in question.