MULTIDRUG RESISTANT UROPATHOGENS IN URINARY TRACT INFECTIONS AND THEIR ANTIBIOTIC SUSCEPTIBILITY PATTERNS

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Muhammad Shabbir
Noor Ul Iman
Muhammad Zahir Shah

Abstract

Objectives: To determine the frequency of multidrug resistant uropathogens and their antibiotic susceptibility patterns.
Material and Methods: This study was conducted in Medical B unit at Khyber Teaching Hospital, Peshawar, Pakistan
from January 2015 to December 2015. A total of 539 cultures were processed and conventional microbiological techniques
were used to isolate MDR and non MDR uropathogens. Antibiotic sensitivities were determined through Kirby
Bauer disc diffusion methods. Data was analyzed through SPSS version 20.
Results: Out of 539 samples cultured, 375 grew significant growth. Mean age was 41.9 ± 18.9SD. UTI was more common
in females (68.3% n=256) than males 31.7% (n=119). E. Coli was the most common organism isolated (78.1%).
Out of 375 isolates, 221 (58.9%) were multidrug resistant. MDR strains were highly sensitive to imipenem (95.1%),
meropenem (95%), tazobactum/piperacillin (92.9%), cefoperazonesulbactum (91.1%) and amikacin (90.1%) and least
sensitive to ampicillin (2.8%) and nalidixic acid (3.5%).
Conclusion: Multidrug resistance in UTI is becoming a major health problem. Assessment of the risk factors, surveillance
of resistance patterns and policies for proper antimicrobial use are urgently warranted.

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