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Objective: To assess the efficacy and safety of misoprostol (PGE1 analogue) for termination of first trimester missed
Material and Methods: A prospective study was carried out from November 2009 to April 2011 at Gynae A unit
Khyber Teaching Hospital Peshawar. A total of 80 patients at 7-12 weeks of gestation requiring termination of
pregnancy were included. Misoprostol 800ug (4 tablets) with 2-3 drops of water was placed high in vagina and then
400 ug (2 tablets) were repeated 6 hourly for 24 hours i.e for 4 doses. The primary outcome measures were complete
evacuation of products of conception, mean induction to expulsion time and the occurrence of side effects.
Results: Successful abortion was observed in 72 (90%) patients. Mean induction to expulsion interval was 13.9
hours. Eight (10.5%) patients had surgical evacuation, of these patients 4 (5%) had incomplete abortion and 4(5%)
had failed induction. Side effects including nausea, vomiting and diarrhea were encountered, very rarely.
Conclusion: Misoprostol is a safe, effective and economical drug for induction of first trimester abortions.
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